Pulmonary Functions and Oxidative Stress Biomarkers Among Silica-Exposed Foundry Workers.

Abstract

To investigate the changes of the ventilatory function tests and the oxidative stress biomarkers among silica-exposed foundry workers. The exposed group included 70 workers in an iron foundry. The nonexposed group included 40 subjects from Kasralainy outpatient clinic. Both groups were subjected to history taking, clinical examination, chest radiograph, spirometry, urinary silica, serum malondialdehyde (MDA), glutathione peroxidase (GPx), and 8-hydroxydeoxyguanosine (8-HdG). Higher urinary silica, serum MDA and serum 8-HdG, whereas lower serum GPx and ventilatory functions were detected in the exposed group compared with the controls. All parameters correlated with urinary silica. The exposed silicotic subgroup had increased work duration, urinary silica, serum MDA, and serum 8-HdG, and decreased serum GPx and ventilatory functions compared with non-silicotic subgroup. Oxidative stress biomarkers were abnormal with impairment of ventilatory functions among silica-exposed workers.