Protecting the kidney in sepsis: resident macrophages to the rescue.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36822750.
- Also identified by DOI 10.1016/j.kint.2022.11.012.
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Abstract
Kidney resident macrophages exert pro-inflammatory or reparative effects in experimental acute kidney injury, but their role in sepsis is unclear. In a mouse model of sepsis, Privratsky et al. show that kidney resident F4/80<sup>hi</sup> macrophages protect against kidney injury by expressing interleukin-1 receptor antagonist, which blocks interleukin-6 production selectively from endothelial cells. Discovery of this novel autocrine loop enhances opportunities for targeted therapies to diminish kidney injury during sepsis.
Medical subject headings
- Acute Kidney Injury
- Sepsis