Changes in Body Mass Index with Longer-term Integrase Inhibitor Use: A Longitudinal Analysis of Data from the Randomized Trial to Prevent Vascular Events in Human Immunodeficiency Virus (REPRIEVE).

Kileel, Emma M; Malvestutto, Carlos D; Lo, Janet; Fitch, Kathleen V; Fichtenbaum, Carl J; Aberg, Judith A; Zanni, Markella V; Martinez, Esteban et al. · Clin Infect Dis · 2023

prospective_cohort · Level II

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Abstract

Over 2-years of follow-up, integrase strand transfer inhibitor (INSTI)-use was associated with weight gain among those on an INSTI <2 years at entry (+0.27 kg/m2/year; 95% confidence interval [CI], .22 to .33 vs +0.17 kg/m2/year; 95% CI, .12 to .23; P = .01), but not those on an entry INSTI >2 years.

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