Clinical features in adults with acquired cutis laxa: a retrospective review.

O'Connell, Katie A; Schaefer, Morgan; Atzmony, Lihi; Vleugels, Ruth Ann; Choate, Keith; LaChance, Avery H; Min, Michelle S · Br J Dermatol · 2023

retrospective_cohort · Level III

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Abstract

Acquired cutis laxa (ACL) is a very rare dermatological condition with numerous proposed aetiologies. Herein, we report on 10 adult patients with ACL, three of which were found to have genetic mutations suggesting a genetic predisposition for the development of ACL following exposure to an environmental insult. Four patients were presumed to develop ACL in association with medication exposure. Overall, if a case of potential ACL arises, providers should carefully review patient history and comorbidities, perform thorough systemic investigations based on symptomatology, and consider genetic analysis.

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