Unraveling barriers to iPSC-derived CAR-T cell differentiation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36868193.
- Also identified by DOI 10.1016/j.stem.2023.02.004.
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Abstract
The generation of off-the-shelf CAR-T cells from TiPSCs has been hindered by the difficulty to recapitulate adaptive T cell development and lower therapeutic efficacy compared to peripheral blood CAR-T cells. Ueda et al. address these issues in a triple-engineering strategy, combining optimized CAR expression with cytolytic and persistence enhancements.
Medical subject headings
- Receptors, Chimeric Antigen
- Induced Pluripotent Stem Cells