Adenoviral gene therapy for bladder cancer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36868210.
- Also identified by DOI 10.1016/j.cell.2023.02.009.
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Abstract
Enhanced by polyamide surfactant Syn3, intravesical administration of rAd-IFNα2b results in transduction of the virus into the bladder epithelium, resulting in the synthesis and expression of local IFNα2b cytokine. Upon secretion, IFNα2b binds to the IFNα receptor on bladder cancer and other cells, resulting in signaling via the JAK-STAT pathway. A plethora of induced IFN-stimulated genes containing IFN-sensitive response elements that contribute to activation of pathways restrict cancer growth.
Medical subject headings
- Janus Kinases
- Urinary Bladder Neoplasms