Structural studies put phage defense mystery on the RADAR.
editorial · Level V
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- Record sourced from PubMed, PMID 36868213.
- Also identified by DOI 10.1016/j.cell.2023.02.003 and PMC identifier 10846546.
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Abstract
Phage restriction by adenosine deaminase acting on RNA (RADAR) is a process by which bacteria may alter their own transcriptome to resist bacteriophage. In this issue of Cell, Duncan-Lowey and Tal et al. and Gao et al. both show RADAR proteins assemble into massive molecular complexes but present distinct views about how these assemblies obstruct phage.
Medical subject headings
- Bacteriophages