Optogenetic rejuvenation of mitochondrial membrane potential extends <i>C. elegans</i> lifespan.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36873708.
- Also identified by DOI 10.1038/s43587-022-00340-7 and PMC identifier 9980297.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Mitochondrial dysfunction plays a central role in aging but the exact biological causes are still being determined. Here, we show that optogenetically increasing mitochondrial membrane potential during adulthood using a light-activated proton pump improves age-associated phenotypes and extends lifespan in <i>C. elegans</i>. Our findings provide direct causal evidence that rescuing the age-related decline in mitochondrial membrane potential is sufficient to slow the rate of aging and extend healthspan and lifespan.
Medical subject headings
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins