Nucleophosmin Plays a Role in Repairing DNA Damage and Is a Target for Cancer Treatment.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 36877156.
- Also identified by DOI 10.1158/0008-5472.CAN-22-3631 and PMC identifier 10183826.
- Licence recorded as CC BY-NC-ND.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Nucleophosmin (NPM1) is frequently mutated in acute myeloid leukemia, and NPM1 expression is elevated in several cancer types. NPM1 is a multifunctional oligomeric protein involved in numerous cellular functions that include participating in liquid-liquid phase separation, ribosome biogenesis, chaperoning of histones, and modulation of transcription. In this review, we discuss the underappreciated role of NPM1 in DNA damage repair, specifically Polη-mediated translesion synthesis, base excision, and homologous recombination and highlight the therapeutic potential of NPM1 targeting in cancer treatment.
Medical subject headings
- Nucleophosmin
- Leukemia, Myeloid, Acute