Trans-segmental imaging in the spinal cord of behaving mice.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36879007.
- Also identified by DOI 10.1038/s41587-023-01700-3 and PMC identifier 11229418.
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Abstract
Spinal cord circuits play crucial roles in transmitting pain, but the underlying activity patterns within and across spinal segments in behaving mice have remained elusive. We developed a wearable widefield macroscope with a 7.9-mm<sup>2</sup> field of view, ~3- to 4-μm lateral resolution, 2.7-mm working distance and <10-g overall weight and show that highly localized painful mechanical stimuli evoke widespread, coordinated astrocyte excitation across multiple spinal segments.
Medical subject headings
- Spinal Cord
- Pain