Rejuvenating muscle stem cells with the glutathione system.
Level V
Where this comes from
- Record sourced from PubMed, PMID 36889277.
- Also identified by DOI 10.1016/j.cmet.2023.02.009.
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Abstract
Aging results from the combination of complex processes still largely undefined. In this issue, Benjamin et al. use multiomic analysis to reveal a causative role of altered glutathione (GSH) synthesis and metabolism in age-dependent muscle stem cell (MuSC) dysfunction, casting light on novel mechanisms regulating stem cell function and on therapeutic approaches to improve defective regeneration in the aged muscle.
Medical subject headings
- Muscle, Skeletal
- Stem Cells