Response to Comment on "Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals".
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- Record sourced from PubMed, PMID 36893240.
- Also identified by DOI 10.1126/science.adf2212.
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Abstract
Herai <i>et al</i>. discuss the known fact that a low percentage of modern humans who lack any overt phenotypes carry the ancestral <i>TKTL1</i> allele. Our paper demonstrates that the amino acid substitution in TKTL1 increases neural progenitor cells and neurogenesis in the developing brain. It is another question if, and to what extent, this has consequences for the adult brain.
Medical subject headings
- Neanderthals
- Neocortex
- Neural Stem Cells
- Neurogenesis
- Transketolase