Comment on "Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals".

Herai, Roberto H; Semendeferi, Katerina; Muotri, Alysson R · Science · 2023

editorial · Level V

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Abstract

Pinson <i>et al</i>. (<i>1</i>) concluded that the modern human <i>TKTL1</i> gene is responsible for an increased number of cortical neurons. We show that the "putative Neanderthal variant" of <i>TKTL1</i> is present in modern human backgrounds. We dispute their argument that this genetic variant is responsible for brain differences in modern humans as opposed to Neanderthals.

Medical subject headings