Cobalt-catalyzed enantioselective intramolecular reductive cyclization via electrochemistry.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36894526.
- Also identified by DOI 10.1038/s41467-023-36704-9 and PMC identifier 9998880.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Transition-metal catalyzed asymmetric cyclization of 1,6-enynes has emerged as a powerful method for the construction of carbocycles and heterocycles. However, very rare examples worked under electrochemical conditions. We report herein a Co-catalyzed enantioselective intramolecular reductive coupling of enynes via electrochemistry using H<sub>2</sub>O as hydride source. The products were obtained in good yields with high regio- and enantioselectivities. It represents the rare progress on the cobalt-catalyzed enantioselective transformation via electrochemistry with a general substrate scope. DFT studies explored the possible reaction pathways and revealed that the oxidative cyclization of enynes by LCo(I) is more favorable than oxidative addition of H<sub>2</sub>O or other pathways.