ANO1 Reprograms Cholesterol Metabolism and the Tumor Microenvironment to Promote Cancer Metastasis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36912612.
- Also identified by DOI 10.1158/0008-5472.CAN-22-3490.
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Abstract
Metastatic cancer cells upregulate ANO1 to activate cell-intrinsic and -extrinsic mechanisms that alter cholesterol metabolism and stimulate fibroblasts, which can be targeted with ANO1 inhibitors to inhibit metastatic growth. See related commentary by Singh and Mehla, p. 1759.
Medical subject headings
- Neoplasm Proteins
- Neoplasms