Measuring biological age using a functionally interpretable multi-tissue RNA clock.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36929664.
- Also identified by DOI 10.1111/acel.13799 and PMC identifier 10186600.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The quantification of the biological age of cells yields great promises for accelerating the discovery of novel rejuvenation strategies. Here, we present MultiTIMER, the first multi-tissue aging clock that measures the biological, rather than chronological, age of cells from their transcriptional profiles by evaluating key cellular processes. We applied MultiTIMER to more than 70,000 transcriptional profiles and demonstrate that it accurately responds to cellular stressors and known interventions while informing about dysregulated cellular functions.
Medical subject headings
- RNA
- Aging