GENLIB: new function to simulate haplotype transmission in large complex genealogies.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36929931.
- Also identified by DOI 10.1093/bioinformatics/btad136 and PMC identifier 10049784.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Founder populations with deep genealogical data are well suited for investigating genetic variants contributing to diseases. Here, we present a major update of the genealogical analysis R package GENLIB, centered around a new function which can simulate the transmission of haplotypes from founders to probands along very large and complex user-specified genealogies. The latest update of the GENLIB package (v1.1.9) contains the new gen.simuHaplo() function and is available on the CRAN repository and from https://github.com/R-GENLIB/GENLIB. Examples can be accessed at https://github.com/R-GENLIB/simuhaplo_functions.
Medical subject headings
- Software
- Population Groups