Cord blood grafts for patients with HIV?
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 36931240.
- Also identified by DOI 10.1016/j.cell.2023.01.024.
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Abstract
Since CCR5 is a key co-receptor for HIV entry into cells, replacing an HIV patient's cells with CCR5-deficient cells is thought to protect the new hematopoietic/immune system from infection. In this issue of Cell, Hsu et al. show that transplanting a cord blood graft carrying the CCR5Δ32 mutation led to a durable HIV remission in a patient with HIV and leukemia.
Medical subject headings
- HIV Infections
- HIV-1