Epigenomic dysregulation correlates with arachnoid cyst formation and neurodevelopmental symptoms.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36932244.
- Also identified by DOI 10.1038/s41591-023-02239-1 and PMC identifier 10233816.
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Abstract
Using a systems-level, multi-omics approach, we reveal several genes associated with arachnoid cysts and identify four phenotypic subtypes of arachnoid cysts, the severity of which correlates with the presence of protein-damaging de novo variants. All candidate genes are expressed in the developing brain and encode molecules implicated in chromatin modification or transcriptional regulation.
Medical subject headings
- Epigenomics
- Arachnoid Cysts