High-resolution separation of bioisomers using ion cloud profiling.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36941278.
- Also identified by DOI 10.1038/s41467-023-37281-7 and PMC identifier 10027677.
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Abstract
Elucidation of complex structures of biomolecules plays a key role in the field of chemistry and life sciences. In the past decade, ion mobility, by coupling with mass spectrometry, has become a unique tool for distinguishing isomers and isoforms of biomolecules. In this study, we develop a concept for performing ion mobility analysis using an ion trap, which enables isomer separation under ultra-high fields to achieve super high resolutions over 10,000. The potential of this technology has been demonstrated for analysis of isomers for biomolecules including disaccharides, phospholipids, and peptides with post-translational modifications.
Medical subject headings
- Disaccharides
- Peptides