Solving the insoluble: calciprotein particles mediate bulk mineral transport.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 36948767.
- Also identified by DOI 10.1016/j.kint.2023.01.011.
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Abstract
Protein mineral complexes, or calciprotein particles, are formed by calcium, phosphate, and the plasma protein fetuin-A. Crystalline calciprotein particles cause soft tissue calcification, oxidative stress, and inflammation, all well-known complications in chronic kidney disease. The T50 calcification propensity test measures how long it takes for amorphous calciprotein particles to crystallize. A study in this volume demonstrates remarkably low calcification propensity in cord blood, despite high mineral concentration. This hints to previously unidentified calcification inhibitors.
Medical subject headings
- Renal Insufficiency, Chronic
- Calcinosis