Phenobarbital for alcohol withdrawal in the context of the opioid epidemic: a neglected caveat.
Where this comes from
- Record sourced from PubMed, PMID 36967706.
- Also identified by DOI 10.1111/add.16194 and PMC identifier 10881280.
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Abstract
Phenobarbital interacts with the mortality-reducing opioid agonist therapies buprenorphine and methadone, risking delayed opioid withdrawal and relapse when administered concurrently. With increased adoption of phenobarbital into alcohol withdrawal protocols there should be safeguards in place to—in most cases—avoid phenobarbital for patients with a concurrent opioid use disorder.
Medical subject headings
- Substance Withdrawal Syndrome
- Alcoholism
- Buprenorphine
- Opioid-Related Disorders