Extrachromosomal Amplification of Human Papillomavirus Episomes Is a Mechanism of Cervical Carcinogenesis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36971511.
- Also identified by DOI 10.1158/0008-5472.CAN-22-3030 and PMC identifier 10239328.
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Abstract
Multimers of the HPV genome are generated in cervical tumors replicating as extrachromosomal episomes, which is associated with deletion and rearrangement of the HPV genome and provides a mechanism for oncogenesis without integration.
Medical subject headings
- Papillomavirus Infections
- Uterine Cervical Neoplasms