Assessment of Microglial Activation in Alzheimer Disease Using 18 F-PBR06 PET.
case_report · Level V
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- Record sourced from PubMed, PMID 36976711.
- Also identified by DOI 10.1097/RLU.0000000000004630.
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Abstract
A 69-year-old woman with progressive short-term memory deficits was diagnosed with Alzheimer disease (MMSE 26/30, CDR 0.5) and underwent PET using 18 F-PBR06, a second-generation 18-kDa translocator protein ligand, targeting brain microglia and astrocytes. SUV and voxel-by-voxel binding potential maps (using simplified reference tissue method and a cerebellar pseudo-reference region) were generated. Images showed evidence of increased glial activation in biparietal cortices (including bilateral precuneus and posterior cingulate gyri) and bilateral frontal cortices. After 6 years of clinical follow-up, patient progressed to moderate cognitive impairment (CDR 2.0) and required assistance for activities of daily living.
Medical subject headings
- Alzheimer Disease