Role of 25-hydroxyvitamin D in irritable bowel syndrome patients.

Alvi, Haris; Ali, Gohar; Iqbal, Sadia; Ahsan, Muhammad Nadeem; Siddiqui, Muhammad Ali; Kirmani, Tooba Ahmed; Irshad, Ghazala; Baktashi, Haisum et al. · J Family Med Prim Care · 2022

prospective_cohort · Level II

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Abstract

We conducted this study on patients diagnosed with irritable bowel syndrome without identifiable stressors and replaced them with vitamin D supplements for 3 months. Almost 97 cases have repeated the vitamin D status that appeared to be sufficient, while 14 patients were missing data for follow-up. The advised option was intramuscular injection replacement but 34 out of 97 were taken oral route for replacement of Vitamin D and incidental finding is noted that serum vitamin D levels rise less in the oral group than in the intramuscular group. Mean age of our subjects was 35.97 ± 9.89 years, comprising 54% males (n = 60) and 46% females (n = 51). In the outcomes of our study, 56.7% of individuals showed complete relief from IBS symptoms after vitamin D replacement, while 36.1% reported considerable improvement. Another 6.2% had exhibited moderate relief with about 14 individuals lost to follow-up.