Interference Between Enteric Viruses and Live-Attenuated Rotavirus Vaccine Virus in a Healthy Australian Birth Cohort.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 37014728.
- Also identified by DOI 10.1093/infdis/jiad094 and PMC identifier 10547457.
- Licence recorded as CC BY-NC-ND.
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Abstract
Rotavirus vaccines have reduced effectiveness in high-mortality settings. Interference between enteric viruses and live-attenuated oral vaccine strains may be a factor. In a birth cohort of healthy Australian infants, parents collected weekly stool samples. Three hundred eighty-one paired swabs collected within 10-days of RotaTeq vaccination from 140 infants were tested for 10 enteric viruses and RotaTeq strains. Collectively, both ribonucleic acid and deoxyribonucleic acid viruses were negatively associated with RotaTeq shedding (adjusted odds ratio = 0.29, 95% confidence interval = 0.14-0.58 and adjusted odds ratio = 0.30, 95% confidence interval = 0.11-0.78, respectively). Enteric viruses may interfere with RotaTeq replication in the gut and thus RotaTeq stool shedding.
Medical subject headings
- Rotavirus
- Rotavirus Infections
- Gastroenteritis
- Rotavirus Vaccines
- Enterovirus Infections