Senescence of bone marrow fat cells: A new clue for glucocorticoid-induced bone deterioration.
Level V
Where this comes from
- Record sourced from PubMed, PMID 37019078.
- Also identified by DOI 10.1016/j.cmet.2023.03.009.
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Abstract
Glucocorticoid (GC)-induced osteoporosis is the most common secondary cause of osteoporosis, resulting in fractures and significant morbidity. In this issue of Cell Metabolism, Liu et al. reveal that in response to GCs, bone marrow adipocytes (BMAds) undergo rapid cellular senescence, triggering secondary senescence in bone marrow and causing bone deterioration.
Medical subject headings
- Glucocorticoids
- Osteoporosis