It takes two to untangle: Combined stimulation of adult neurogenesis reverts AD symptoms.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 37028395.
- Also identified by DOI 10.1016/j.stem.2023.03.012.
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Abstract
Alzheimer's disease (AD) is associated with reduced adult hippocampal neurogenesis and impaired hippocampal-dependent behaviors. Li et al.<sup>1</sup> report that stimulating adult neurogenesis combined with new-born neuron activation ameliorates behavioral symptoms and plaque deposition in AD mouse models. This supports boosting adult neurogenesis as a potential therapeutic approach for AD-related cognitive decline.
Medical subject headings
- Alzheimer Disease