A mechanical niche promotes the rejuvenation of blood stem cells.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 37028397.
- Also identified by DOI 10.1016/j.stem.2023.03.015.
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Abstract
Zhang et al.<sup>1</sup> show that the mechanical properties of a three-dimensional (3D) hydrogel can enhance the secretion of niche factors from bone marrow stromal cells, which in turn promotes the maintenance of hematopoietic stem cells (HSCs) and reverses aging hallmarks in HSCs.
Medical subject headings
- Bone Marrow Cells
- Mesenchymal Stem Cells