A nonstop thrill ride from genes to the assembly of the T3SS injectisome.
basic_science · Level V
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- Record sourced from PubMed, PMID 37031218.
- Also identified by DOI 10.1038/s41467-023-37753-w and PMC identifier 10082841.
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Abstract
The type three secretion system (T3SS) is a membrane-anchored nano-machine utilized by many pathogenic bacteria to inject effector proteins and thus take control of host cells. In a recent article, Kaval et al. reveal a striking colocalization of a T3SS-encoding locus, its transcriptional activators, protein products, and the complete structure at the cell membrane, which they claim provides evidence for a mechanism known as ‘transertion’.