The Beneficial Effects of Lactobacillus GG Therapy on Liver and Drinking Assessments in Patients with Moderate Alcohol-Associated Hepatitis.
rct · Level II
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- Record sourced from PubMed, PMID 37040544.
- Also identified by DOI 10.14309/ajg.0000000000002283 and PMC identifier 10524173.
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Abstract
We investigated the effect of daily oral Lactobacillus rhamnosus GG (LGG) in reducing liver injury/severity and drinking in patients with alcohol use disorder and moderately severe alcohol-associated hepatitis. Forty-six male and female individuals with alcohol use disorder and moderate alcohol-associated hepatitis (12 ≤ model for end-stage liver disease score < 20, aged 21-67 years) received either LGG (n = 24) or placebo (n = 22). Data were collected/assessed at baseline and at 1, 3, and 6 months. LGG treatment was associated with a significant reduction in liver injury after 1 month. Six months of LGG treatment reduced heavy drinking levels to social or abstinence levels. LGG treatment was associated with an improvement in both liver injury and drinking.
Medical subject headings
- Alcoholism
- End Stage Liver Disease
- Hepatitis, Alcoholic
- Lacticaseibacillus rhamnosus
- Probiotics