Remote Hemorrhagic Complications of Glioma Surgery: Systematic Review of the Literature and Report of a Case of Distant Wounded Glioma Syndrome, a Rare Neurosurgical Complication.

Abstract

Hemorrhage following glioma resection usually happens in tissues that were surgically manipulated. Remote bleeding is a rare and serious complication that is still poorly understood. Distant wounded glioma syndrome is a special type of this complication, where bleeding happens in a glioma lesion that was not surgically manipulated. A systematic review was conducted on the MEDLINE and Scielo databases. A new case of distant wounded glioma syndrome was reported and added to the results. We identified 501 articles using the search strategy and screened them. We reviewed the full text of 58 articles, of which 4 met the eligibility criteria. Including our new case, only 5 articles reported hemorrhage in locations remote from the resection site, with a total of 6 patients. Remote bleeding, including distant wounded glioma syndrome, is a rare complication that should be considered in cases of postoperative deterioration, especially in cases of symptoms not congruent with the operated site.