Structural insights into how augmin augments the mitotic spindle.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 37055387.
- Also identified by DOI 10.1038/s41467-023-37625-3 and PMC identifier 10102323.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Cell division critically requires amplification of microtubules (MTs) in the bipolar mitotic spindle. This relies on the filamentous augmin complex that enables MT branching. Studies by Gabel et al., Zupa et al. and Travis et al. describe consistent integrated atomic models of the extraordinarily flexible augmin complex. Their work prompts the question: what is this flexibility really needed for?
Medical subject headings
- Spindle Apparatus
- Microtubules