Pancreatic cancer: Advances and challenges.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 37059070.
- Also identified by DOI 10.1016/j.cell.2023.02.014 and PMC identifier 10182830.
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Abstract
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers. Significant efforts have largely defined major genetic factors driving PDAC pathogenesis and progression. Pancreatic tumors are characterized by a complex microenvironment that orchestrates metabolic alterations and supports a milieu of interactions among various cell types within this niche. In this review, we highlight the foundational studies that have driven our understanding of these processes. We further discuss the recent technological advances that continue to expand our understanding of PDAC complexity. We posit that the clinical translation of these research endeavors will enhance the currently dismal survival rate of this recalcitrant disease.
Medical subject headings
- Carcinoma, Pancreatic Ductal
- Pancreatic Neoplasms