Exploiting metabolic vulnerabilities in breast cancers with NF1 loss.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 37075699.
- Also identified by DOI 10.1016/j.xcrm.2023.101010 and PMC identifier 10140605.
- Licence recorded as CC BY-NC-ND.
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Abstract
Auf der Maur et al.<sup>1</sup> identify neurofibromin 1 (NF1) loss as a mechanism of resistance to PI3K inhibitor in breast cancer cells. NF1 loss leads to enhanced glycolysis, which may be targeted with the antioxidant N-acetyl cysteine (NAC).
Medical subject headings
- Breast Neoplasms
- Biochemical Phenomena