Copper-catalyzed asymmetric C(sp<sup>2</sup>)-H arylation for the synthesis of P- and axially chiral phosphorus compounds.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 37081007.
- Also identified by DOI 10.1038/s41467-023-37987-8 and PMC identifier 10119316.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Transition metal-catalyzed C-H bond functionalization is an important method in organic synthesis, but the development of methods that are lower cost and have a less environmental impact is desirable. Here, a Cu-catalyzed asymmetric C(sp<sup>2</sup>)-H arylation is reported. With diaryliodonium salts as arylating reagents, a range of ortho-arylated P-chiral phosphonic diamides were obtained in moderate to excellent yields with high enantioselectivities (up to 92% ee). Meanwhile, enantioselective C-3 arylation of diarylphosphine oxide indoles was also realized under similar conditions to construct axial chirality.