Single-cell transcriptomics of a dynamic cell behavior in murine airways.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 37083555.
- Also identified by DOI 10.7554/eLife.76645 and PMC identifier 10174686.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Despite advances in high-dimensional cellular analysis, the molecular profiling of dynamic behaviors of cells in their native environment remains a major challenge. We present a method that allows us to couple the physiological behaviors of cells in an intact murine tissue to deep molecular profiling of individual cells. This method enabled us to establish a novel molecular signature for a striking migratory cellular behavior following injury in murine airways.
Medical subject headings
- Transcriptome
- Gene Expression Profiling