Combination therapy for painful diabetic neuropathy is safe and effective.

Saul, Helen; Deeney, Brendan; Imison, Candace; Tesfaye, Solomon · BMJ · 2023

rct · Level II

Where this comes from

Abstract

The studyTesfaye S, Sloan G, Petrie J, et al. Comparison of amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin for the treatment of diabetic peripheral neuropathic pain (OPTION-DM): a multicentre, double-blind, randomised crossover trial. <i>Lancet</i> 2022;400:680-90.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/combination-therapy-for-painful-diabetic-neuropathy-is-safe-and-effective/.

Medical subject headings