ER stress and slit diaphragms: is there a connection?
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 37085254.
- Also identified by DOI 10.1016/j.kint.2023.01.028.
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Abstract
Galloway-Mowat syndrome is a neurorenal syndrome that has been linked with defective transfer RNA and protein translation caused by variants in the multiprotein complex KEOPS. In the kidney, this syndrome seems to primarily affect the podocytes, but the pathogenesis has remained unclear. In this issue of Kidney International, Krausel et al. use Drosophila nephrocytes to link endoplasmic reticulum stress with defects in the slit diaphragm.
Medical subject headings
- Podocytes
- Nephrosis
- Drosophila Proteins