Heparin Prowess: Favorable Vascular-Immune Reprogramming in Pancreatic Cancer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 37099035.
- Also identified by DOI 10.1158/1078-0432.CCR-23-0346 and PMC identifier 10320458.
- Licence recorded as CC BY-NC-ND.
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Abstract
Several approaches for overcoming immunotherapy resistance in pancreatic and colorectal cancer syngeneic models were assessed using heparin and immunotherapy. Beneficial responses were attributed to heparin-induced vascular normalization, ensuing CD8+ T-cell infiltration, and M1 macrophage polarization, suggesting the potential for heparin-anchored therapies in cold tumors such as pancreatic cancer. See related article by Wei et al., p. 2525.
Medical subject headings
- Heparin
- Pancreatic Neoplasms