Dynamic covalent nano-networks comprising antibiotics and polyphenols orchestrate bacterial drug resistance reversal and inflammation alleviation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 37113688.
- Also identified by DOI 10.1016/j.bioactmat.2023.04.014 and PMC identifier 10126917.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
New antimicrobial strategies are urgently needed to meet the challenges posed by the emergence of drug-resistant bacteria and bacterial biofilms. This work reports the facile synthesis of antimicrobial dynamic covalent nano-networks (aDCNs) composing antibiotics bearing multiple primary amines, polyphenols, and a cross-linker acylphenylboronic acid. Mechanistically, the iminoboronate bond drives the formation of aDCNs, facilitates their stability, and renders them highly responsive to stimuli, such as low pH and high H<sub>2</sub>O<sub>2</sub> levels. Besides, the representative <b>A1B1C1</b> networks, composed of polymyxin B1(<b>A1</b>), 2-formylphenylboronic acid (<b>B1</b>), and quercetin (<b>C1</b>), inhibit biofilm formation of drug-resistant <i>Escherichia coli</i>, eliminate the mature biofilms, alleviate macrophage inflammation, and minimize the side effects of free polymyxins. Excellent bacterial eradication and inflammation amelioration efficiency of <b>A1B1C1</b> networks are also observed in a peritoneal infection model. The facile synthesis, excellent antimicrobial performance, and biocompatibility of these aDCNs potentiate them as a much-needed alternative in current antimicrobial pipelines.