Transient perinatal metabolic shifts determine neuronal survival and functional circuit formation.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 37116467.
- Also identified by DOI 10.1016/j.cell.2023.03.027.
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Abstract
Metabolic changes are essential for neurodevelopmental processes. However, little is known about how and when neuronal metabolic remodeling occurs to promote functional circuits. In this issue of Cell, Knaus et al. demonstrate that a temporary perinatal shift in metabolites and lipids is crucial for cortical neurons' survival and wiring.
Medical subject headings
- Neurons