Translocating Lactobacillus torments tumors via tryptophan catabolism.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 37116468.
- Also identified by DOI 10.1016/j.cell.2023.03.022.
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Abstract
Variability in the efficacy of immune checkpoint inhibitors in cancer patients is associated with the human gut microbiota. However, detailed mechanisms are unclear. In this issue of Cell, Bender et al. uncovered that a probiotic Lactobacillus strain translocates into murine tumors to enhance immunotherapy via the tryptophan metabolite indole-3-aldehyde (I3A).
Medical subject headings
- Gastrointestinal Microbiome
- Lactobacillus
- Neoplasms
- Tryptophan