Gut mitochondrial defects drive neurodegeneration.
Where this comes from
- Record sourced from PubMed, PMID 37117753.
- Also identified by DOI 10.1038/s43587-022-00206-y and PMC identifier 11034919.
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Abstract
Neurodegenerative diseases, including Parkinson’s disease, are linked to the accumulation of defective mitochondria in the brain and to microbial dysbiosis in the gut. However, the interplay between these factors is incompletely understood. Fedele et al. reveal how gut mitochondrial dysfunction activates intestinal inflammation to drive neurodegeneration in a Parkinson’s disease model.
Medical subject headings
- Mitochondria
- Nerve Degeneration