The energy-splicing resilience axis hypothesis of aging.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 37118371.
- Also identified by DOI 10.1038/s43587-022-00189-w and PMC identifier 11330567.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Aging can be conceptualized as the stochastic accumulation of damage and loss of resilience leading to organism demise. Resilience mechanisms that repair, recycle or replace damaged molecules and organelles are energy-demanding, therefore energy availability is essential to healthy aging. We propose that changes in mitochondrial and energy status regulate RNA splicing and that splicing is a resilience strategy that preserves energetic homeostasis with aging.
Medical subject headings
- RNA Splicing
- Aging