The secret life of lactate: A novel cell-cycle regulatory mechanism.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 37137286.
- Also identified by DOI 10.1016/j.cmet.2023.04.006 and PMC identifier 12814974.
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Abstract
Recently, Liu et al. uncovered an unexpected L-lactate-Zn<sup>2+</sup> interaction in the active site of the deSUMOylating enzyme SENP1 that triggers a sequence of events that lead to mitotic exit. This study opens the door to new research avenues of metabolite-metal interactions controlling cellular decisions and functions.
Medical subject headings
- Lactic Acid
- Mitosis