Breathing-induced forces influence lung cell fate.

Yang, Min-Chi; Rea-Moreno, Martha G; Chen, Ya-Wen · Cell Stem Cell · 2023

editorial · Level V

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Abstract

Respiration exerts a mechanical strain on the lungs, which has an unclear effect on epithelial cell fate. Now in Cell, Shiraishi et al.<sup>1</sup> reveal the crucial role of mechanotransduction in maintaining lung epithelial cell fate, representing a significant milestone in understanding how mechanical factors regulate differentiation.

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