Roles of adenine methylation in the physiology of Lacticaseibacillus paracasei.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 37149616.
- Also identified by DOI 10.1038/s41467-023-38291-1 and PMC identifier 10164179.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Lacticaseibacillus paracasei is an economically important bacterial species, used in the food industry and as a probiotic. Here, we investigate the roles of N6-methyladenine (6mA) modification in L. paracasei using multi-omics and high-throughput chromosome conformation capture (Hi-C) analyses. The distribution of 6mA-modified sites varies across the genomes of 28 strains, and appears to be enriched near genes involved in carbohydrate metabolism. A pglX mutant, defective in 6mA modification, shows transcriptomic alterations but only modest changes in growth and genomic spatial organization.
Medical subject headings
- Lacticaseibacillus
- Lacticaseibacillus paracasei