Response to Comment on "Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice".

Albornoz, Eduardo A; Gordon, Richard; Kumar, Vinod; Robertson, Avril A B; Schroder, Kate; Woodruff, Trent M · Sci Transl Med · 2023

basic_science · Level V

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Abstract

We have replicated our original finding of elevated cleaved caspase-1 in mouse brains and neuroprotection by an NLRP3 inflammasome inhibitor in two mouse models of Parkinson's disease.

Medical subject headings