Air pollution, EGFR mutation, and cancer initiation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 37196632.
- Also identified by DOI 10.1016/j.xcrm.2023.101046 and PMC identifier 10213952.
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Abstract
Swanton et al.<sup>1</sup> find that PM<sub>2.5</sub> exposure is associated with EGFR/KRAS-driven lung cancer incidence. PM<sub>2.5</sub> increases EGFR pre-mutated alveolar type II cell progenitor function and tumorigenic activity through interstitial macrophage-secreted IL-1β, providing potential prevention approaches to inhibit cancer initiation.
Medical subject headings
- Air Pollution
- Lung Neoplasms